![]() ![]() ![]() As a result, studies on PUFA show inconsistent results about the role of PUFA in health and disease 8, 9. It is challenging to clarify the differential effects of n-6 and n-3 PUFA or varying n-6/n-3 PUFA ratios due to the confounding factors of diet 6, 7. Recent research has focused mainly on overall PUFA levels or on the level of n-3 PUFA alone, ignoring the important interplay between n-6 and n-3 PUFA levels 4, 5. These diseases are multi-factorial in nature, but their prevalence coincides with the unbalanced increase in dietary omega-6 (n-6) polyunsaturated fatty acids (PUFA) and decrease in omega-3 (n-3) PUFA in today’s diets, suggesting that there may be differential effects of n-6 and n-3 PUFA on the development of chronic disease 2, 3. ![]() Chronic illnesses, including obesity, type 2 diabetes, cardiovascular disease, cancer, and Alzheimer’s disease, are rising exponentially in the modern world 1. ![]()
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